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Chronic Pain Conditions · Concern

Chronic Pain Syndrome

A diagnosis that names a pattern without telling you what's causing your pain. Sometimes it reflects real nervous-system changes; sometimes it's a placeholder for an unidentified source. The first step is figuring out which one applies to you, because that changes everything.

Medically Reviewed By
Nadiv Y. Samimi
Faisal Lalani
Nadiv Y. Samimi, MD & Faisal Lalani, MD MD
Last reviewed · June 4, 2026
IN SHORT

Chronic pain syndrome describes a pattern, not a cause, and the first step is figuring out whether a specific source exists. At PHI in Beverly Hills, board-certified physicians Dr. Faisal Lalani and Dr. Nadiv Samimi re-evaluate thoroughly and offer nerve blocks, radiofrequency ablation, peripheral nerve stimulation, and ketamine for the nervous system sensitization that maintains chronic pain.

What Chronic Pain Syndrome Actually Means

If you have been diagnosed with chronic pain syndrome, you may already know that the term does not tell you much. It describes a pattern, pain that has persisted longer than expected, often with multiple contributing factors, but it does not identify what is actually causing your pain or what to do about it.

In some cases, chronic pain syndrome is a legitimate diagnosis describing real changes in how your nervous system processes pain: signals that originally indicated tissue damage continue to fire after the original cause has resolved, the nervous system becomes increasingly sensitized, and sleep, mood, and quality of life are affected. In other cases, it is essentially a placeholder diagnosis used when previous evaluation has not identified a clearer source. The first step in our approach is figuring out which one applies to you, because for some patients a more focused evaluation reveals a specific treatable source, and for others the diagnosis is accurate and the focus shifts to treatments that address nervous system sensitization directly.

When Chronic Pain Syndrome Has a Specific Source

For some patients labeled with chronic pain syndrome, focused evaluation reveals a more specific underlying condition that responds well to targeted treatment. Examples include facet-mediated spinal pain that has not been correctly identified, sacroiliac joint dysfunction treated as general back pain, specific nerve entrapments or peripheral neuropathies, vertebrogenic pain patterns, and joint or tendon issues that fit regenerative treatment.

When this is the case, the right treatment is usually the one specific to the underlying condition rather than a generic chronic pain approach. We route patients to the appropriate evaluation and discuss this on the related condition pages.

When Chronic Pain Syndrome Is the Accurate Diagnosis

For other patients, the diagnosis is accurate, and the focus shifts to treatments that address chronic nervous system sensitization directly, working through different mechanisms than standard injections or medications.

Nerve blocks can interrupt specific pain pathways and sometimes produce sustained relief that outlasts the local anesthetic, and successful blocks can also be diagnostic. Radiofrequency ablation disrupts the nerves carrying pain signals from specific structures, providing longer-lasting relief for selected patients. Peripheral nerve stimulation uses small electrical signals to interrupt chronic pain signaling along specific nerves; for patients whose pain has a focal nerve distribution, the 60-day temporary system can produce meaningful relief without the systemic effects of long-term medications. Ketamine infusion therapy acts on a different pathway than most pain medications, with accumulating evidence for chronic pain involving central sensitization, particularly when pain coexists with mood overlap or sleep disruption; PHI administers physician-monitored ketamine in a clinic setting.

When to See Someone

Consider professional evaluation when you have been managing chronic pain for months or years without lasting relief, when standard treatments have not produced adequate response, when you are tired of the trial-and-error approach with medications, when you want a thorough re-evaluation to see whether a more specific source can be identified, when you are interested in treatments like ketamine infusion or peripheral nerve stimulation that are not widely available, or when you want a clear plan rather than continued symptom management without direction.

Why PHI for Chronic Pain Syndrome

i.

Two board-certified pain physicians

Dr. Faisal Lalani and Dr. Nadiv Samimi both fellowship-trained at Cedars-Sinai, with extensive experience with complex chronic pain patients who have not responded to prior treatment.

ii.

Comprehensive re-evaluation

Many patients with chronic pain syndrome have not been thoroughly re-evaluated in years. A focused assessment sometimes reveals options that were not previously considered. We take the time to do that work.

iii.

Access to ketamine infusion therapy

PHI offers physician-administered ketamine infusion in a clinic setting, one of the most clinically interesting recent developments for chronic pain and not widely available even at larger pain practices.

iv.

Peripheral nerve stimulation

PHI offers the 60-day temporary peripheral nerve stimulation system. For appropriate candidates, this can produce meaningful relief without the side effects of chronic medications.

v.

Honest framing

If your pain points to a specific source we can treat directly, we tell you. If it points to a need for coordinated care with other specialists, we tell you that too. The goal is your relief, not selling you on a treatment.

vi.

Concierge, coordinated care

Single-physician continuity from consultation through treatment and return to activity. Patients receive clear guidance and transparent pricing at consultation.

Frequently Asked Questions

Yes, when used appropriately. It describes real biological changes in how the nervous system processes pain, often after months or years of ongoing pain signals. The challenge is that the term is sometimes used as a placeholder when more specific evaluation has not been done, which is why thorough re-evaluation often matters.

Treatments We Offer for Chronic Pain Syndrome

PHI offers evidence-based treatments for chronic pain syndromes. Your physician will recommend the right option, or combination, based on your specific situation, what you have tried, and your goals.

Schedule Your Chronic Pain Syndrome Consultation

A 60-minute consultation will thoroughly re-evaluate your situation, identify whether more specific diagnostic options exist, and walk through the treatment options that match your specific condition. Call (310) 856-9488 or book online now.

Begin a consultation

Schedule with PHI.

A 60-minute consultation includes history, imaging review, and an honest discussion of whether interventional or regenerative care is the right next step for you.