Stem Cell Therapy

The artistry of the human body is incredible. All cells play a role in our well being. How can we best utilize these cells?

A Total Biologic Stem Cell doctor will utilize cells harvested from bone marrow and/or adipose. This type of autologous stem cell therapy offers the patient a stem cell treatment plan best suited for their injury or disease.

Throughout the world, scientists are trying to uncover the mystery of the cell as you can see in the video trailer for "Stem Cell Revolutions"

Stem Cell Therapy is growing across the globe. Pioneers in research and in the clinic are developing new biologic treatments for many types of diseases and injury. The video trailer above examines this in the documentary “Stem Cell Revolutions” Entire documentary is available on Amazon Video. Click Here to learn more about these scientists.

More and More studies are done on Stem Cell effectiveness

Adult Human Mesenchymal Stem Cells Delivered via
Intra-Articular Injection to the Knee Following
Partial Medial Meniscectomy

C. Thomas Vangsness Jr., MD, Jack Farr II, MD, Joel Boyd, MD, David T. Dellaero, MD, C. Randal Mills, PhD,
and Michelle LeRoux-Williams, PhD

Investigation performed at the University of Southern California Orthopaedic Surgery Associates, Keck School of Medicine, Los Angeles, California, Unlimited Research, San Antonio, Texas, Triangle Orthopaedic Associates, Durham, North Carolina, Orthopaedic Center of Vero Beach, Vero Beach, Florida, OrthoIndy, Indianapolis, Indiana, TRIA Orthopaedic Center, Bloomington Minnesota, and Greater Chesapeake Orthopaedic Associates, Baltimore, Maryland

Background

There are limited treatment options for tissue restoration and the prevention of degenerative changes in the knee. Stem cells have been a focus of intense preclinical research into tissue regeneration but limited clinical investigation. In a randomized, double-blind, controlled study, the safety of the intra-articular injection of human mesenchymal stem cells into the knee, the ability of mesenchymal stem cells to promote meniscus regeneration following partial meniscectomy, and the effects of mesenchymal stem cells on osteoarthritic changes in the knee were investigated.

Methods

A total of fifty-five patients at seven institutions underwent a partial medial meniscectomy. A single superolateral knee injection was given within seven to ten days after the meniscectomy. Patients were randomized to one of three treatment groups: Group A, in which patients received an injection of 50 · 106 allogeneic mesenchymal stem cells; Group B, 150 · 106 allogeneic mesenchymal stem cells; and the control group, a sodium hyaluronate (hyaluronic acid/ hyaluronan) vehicle control. Patients were followed to evaluate safety, meniscus regeneration, the overall condition of the knee joint, and clinical outcomes at intervals through two years. Evaluations included sequential magnetic resonance

imaging (MRI).

Results

No ectopic tissue formation or clinically important safety issues were identified. There was significantly increased meniscal volume (defined a priori as a 15% threshold) determined by quantitativeMRI in 24%of patients in Group A and 6% in Group B at twelve months post meniscectomy (p = 0.022). No patients in the control group met the 15% threshold for increased meniscal volume. Patients with osteoarthritic changes who received mesenchymal stem cells experienced a significant reduction in pain compared with those who received the control, on the basis of visual analog scale assessments.

Conclusions: There was evidence of meniscus regeneration and improvement in knee pain following treatment with allogeneic human mesenchymal stem cells. These results support the study of human mesenchymal stem cells for the apparent knee-tissue regeneration and protective effects.s.

Stem Cells from Bone Marrow Aspirate

Concentrated Bone Marrow is designed to provide significant concentrations of CFU-F, CD34+, and total nucleated cell counts. CD34+ are cell markers for hematopoietic stem cells. These are the primary multipotent cells that replenishes all blood cell types. These cells are crucial for the regenerative processes needed for active tissue repair. In addition to these cells are CFU-F, which are representative of mesenchymal stem cells.

Mesenchymal stem cells (MSC) are multipotent stromal cells that can differentiate into a variety of cell types, including cartilage, bone and adipose cells. BMC provides therapeutic concentrations of these cell types which is the key to desirable patient outcomes.

Stem Cells from Adipose

Adipose is used in regenerative medicine procedures because mesenchymal stem cells can be isolated from almost every tissue in the human body. The central connecting aspect to explain this fact is that all of these tissues are vascularized and that every blood vessel in the body has mesenchymal cells in abluminal locations. These perivascular cells can be summarily called Pericytes.

Adipose-Derived MSCs are being used therapeutically because they undergo homing to sites of inflammation or tissue injury and they secrete massive levels of bioactive agents that are both immunomodulatory and trophic.